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At a normal therapeutic dose, acetaminophen is primarily metabolized by the liver to sulfate and glucuronide conjugates, while a SMALL amount is metabolized by CYP2E1 to a highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI)

Ann Rev Biochem 49:517531 Fox PF, Uniacke-Lowe T, McSweeney PLH, OMahony JA (1998) Dairy chemistry and biochemistry

In contrast to neurons, astrocytes can efficiently metabolize FAs, and FA oxidationpredominantly in astrocytescontributes ~ 20% of the total brain energy supply (Zhang et al., 2023, 2024b)

In mammalian genomic DNA, about 5% of cytosine exists as 5mC

In detail, SSa downregulates TLR4 and NF-B while BDNF is upregulated, promoting the alleviation of depressive-like behaviors in CUMS-induced mice (Tan et al., 2025)