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Additionally, the analgesic effect of methadone is shorter than the pharmacologic half-life, leading to potential additive respiratory depression if the medication is dosed solely based on pain

GABA itself is also listed as an illegal drug in these jurisdictions, which seems unusual given its failure to cross the bloodbrain barrier, but there was a perception among legislators that all known analogues should be covered as far as this was possible

PMID 10739172

Related to this, Rodriguez-Perez and colleagues (110, 129) used intrastriatal 6-OHDA injections to produce dopaminergic degeneration and noted a significant decrease in DA neurons in ovariectomized rats