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Preclinical studies have shown that the subtherapeutic dose of local RT combined with NKG2D-based CAR T cells can promote the migration of CAR-T cells to the tumor site, resulting in a synergistic effect in two independent syngeneic mouse glioma models (101)

Here, we detected an increase in PGC-1 with 2 weeks of glutathione intake, along with an increase in mtDNA content, indicating the activation of mitochondrial biogenesis

This clonality indicates that, out of many combinations of stochastic events or changes of signaling, only one event combination has initially led to one tumor

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