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Additional investigations may be requested when results are equivocal or to establish the underlying cause: Holotranscobalamin (active B12) : Available in some UK laboratories and may be more sensitive for detecting early deficiency

252 Clinically, in a study involving 27 patients with low-grade non-Hodgkin lymphoma, direct injection of SD-101 into tumors combined with low-dose radiation therapy not only activated local immune responses but also induced systemic abscopal effects

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Scientific Context| One compound that has attracted attention in metabolic and neurological research is Vitamin B12 (commonly cyanocobalamin or methylcobalamin), an essential nutrient involved in red blood cell formation, DNA synthesis, and energy metabolism