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However, the clinical use of aptamers is limited by their susceptibility to degradation by nucleases and possible renal clearance, both of which shorten their therapeutic window

[DOI] [PubMed] [Google Scholar] 39.Xie Y, McGill MR, Dorko K, Kumer SC, Schmitt TM, Forster J, Jaeschke H

Metformin treatment with concentrations of 10, 25, and 50 M significantly restored chondrocyte viability suppressed by H 2 O 2 exposure, and 50 M metformin was chosen for further studies (Fig