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Minihepcidins are synthetic peptides encompassing 79 amino acids at the N-terminal of hepcidin, being capable of binding to iron transporter proteins and inducing their degradation ( The inhibitor of transmembrane protease serine 6 (TMPRSS6) is capable of effectively reducing the degradation effect of TMPRSS6 on hepcidin ( Another approach is to employ iron transporter protein inhibitors (VIT-2763) to restriction the availability of iron, thereby mitigating ineffective erythropoiesis and iron overload (150)

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Haematologica 2007

doi: 10.1155/2019/9542656 44 GaudenzioNSibilanoRMarichalTStarklPReberLLCenacNet al