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In this work, the main phenotypic screening was fundus photography followed by scoring of yellow fundus spots using a special fundus spot scale (see below)

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Plaque rupture leads to acute exposure of procoagulant and prothrombotic factors from the necrotic core of the lesion to platelets and procoagulant factors in the lumen, thereby causing thrombus formation (Figure 5) (168,169)

This dysregulation can be achieved by directly oxidizing critical biomolecules (DNA, proteins, lipids) and thereby disrupting essential cellular signaling pathways