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demonstrated that single nucleotide polymorphisms (SNPs) of the AS3MT gene ought to be considered when determining the therapeutic dose of ATO, and that the urinary primary methylation index (PMI) can be used as a monitoring indicator of ATO-related chronic adverse reactions (AEs) (Zheng et al., 2021)

The DEGs were further aligned with six databases: GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes), NR (NCBI non-redundant protein sequences), KOG (a cluster of orthologous groups), Pfam (protein family), and Swiss-Prot (a manually annotated and reviewed protein sequence database)

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doi:10.1017/S109285292100002X

Furthermore, the review cites a growing body of data showing that Zn both inhibits NADPH oxidase, an enzyme implicated in ROS generation, and boosts glutathione synthesis, a potent antioxidant