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Nat Rev Rheumatol (2012) 8:65664

In trabeculectomy samples, hypomethylation of Alu elements was noted across all glaucoma subtypes, while hypermethylation of HERV-K was specific to primary open-angle glaucoma patients, both alterations are associated with TM fibrosis and contribute to increased IOP (Chansangpetch et al., 2018)