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Ornithine (an arginine byproduct) suppressed the metabolism of CD8 + T cells, reducing the intracellular levels of adenosine triphosphate (ATP), and, at the same time, increasing the resistance of tumor cells to CD8 + T cells-mediated cytotoxicity [87]

The elevated Ca 2+ concentration upregulates the activity of nNOS, contributes to mitochondrial activity deregulation and ER stress, leading to cell membrane depolarization and dysfunction of intracellular organelles

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Both oral cyanocobalamin and injectable hydroxocobalamin list diarrhoea as a rare adverse reaction in UK product information

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