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After IVD degeneration (IDD), due to CEP calcification and reduced vertebral blood supply, the glucose concentration in the NP further decreases, with an average concentration in degenerated human NP being only 0.603 0.108 mM (Yin et al., 2020), approaching the minimum threshold required for IVD cell survival (0.5 mM) ( Under low glucose conditions, mesenchymal stem cells (MSCs) exhibit certain adaptive responses

By supporting detoxification processes in the liver, glutathione can help neutralize and eliminate toxic substances

Research in centenarians found that 6 months of L-Carnitine treatment (2 g/day) significantly increased muscle mass while reducing total body fat, alongside improvements in walking capacity and physical function

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Activation of nonhomologous end joining (NHEJ) for DNA double-strand break repair necessitates a decrease in Beclin-1-UVRAG activity to uphold genome stability (247)