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More importantly, their long-term exposures have been correlated with gastrointestinal and renal dysfunction, cardiovascular damage, immunological dysregulation, cancer, neurotoxicity, and congenital abnormalities [27,28] (Figure 1)

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells

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For co-immunoprecipitation assay, the expression vector of FLAG-PGRMC1 or an empty vector into HCT116 by using a transfection reagent Lipofectamine 2000 (Invitrogen)