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Statements Author contributions P-DL: Conceptualization, Writingoriginal draft, Writingreview and editing

Doyle P'20 Leo F

Notably, in some specific tumors such as breast cancer, mentioned above, the accumulating zinc levels are also observed in malignant tissues 29

reported for the first time that osteomalacia occurred in 4 patients who used phenytoin, primidone, and phenobarbitone for long-term antiseizure therapy, possibly because drug-mediated enzyme induction led to a significant increase in the degree of vitamin D inactivation ( The relationship between vitamin D supplementation and SF in patients with DRE is controversial

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