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Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue

This complementary mechanism preserves natural feedback loops while significantly amplifying growth hormone secretion, distinguishing it from continuous, non-pulsatile stimulation approaches that may lead to receptor desensitization

arXiv preprint arXiv:1810.04805

Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis

(c) World Health Organization, Geneva, 1993 and ECSC-EEC-EAEC, Brussels-Luxembourg, 1993 First published 1993 Publication No