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When ADH5 expression is reduced in certain organs and cell types in individuals with dominant-negative ALDH2*2 alleles, the ability to metabolize endogenous formaldehyde may be significantly reduced, possibly resulting in endogenous formaldehyde accumulation

Some patients might also experience headaches, lightheadedness, or stomach upset, such as mild nausea [2]

As well as frequent urination, the disease was also known to cause excessive thirst and weight loss

Pharmaceutics 12, (2020), Abstract BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis: Yang, X., Ge, L., et al

10.1186/s40168-024-01858-1 [DOI] [PMC free article] [PubMed] [Google Scholar] Bravo J