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Nicotinamide reduces the PARP activity and also increases the NAD + NADH levels in the pancreatic beta cells, enhancing the activity of superoxide mutase which counteracts ROS [109]

Despite the great effects of these drugs in controlling hyperthyroidism, their administration is associated with hepatotoxicity as a serious side effect.8,9 Hepatic injury induced by these agents could be so severe that might lead to hepatic failure and requirement for liver transplantation,10,11,12 and even death has been reported in some cases.13,14 Liver transaminase abnormality, that might indicate subclinical liver injury, is a common event after PTU administration.12,15 Kim et al

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Regulation of intracellular glutathione[J]