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In this context, buthionine sulfoximine (BSO) is the most popular GSH-depleting agent studied in both preclinical and early clinical trials, but limitation on its availability has led to a search for alternatives [13, 14]

At the same time, the conjugation of glutathione with toxins helps to detoxify and eliminate fat-soluble toxins and heavy metals

50 Because of the chronicity of the condition, these costs typically persist over years