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Description

2021;10(9):e2001941

Class I ferroptosis inducers (FINs), including sorafenib, sulfasalazine, erastin, and its analog imidazole ketone erastin, inhibit system Xc-, disturb the synthesis of GSH, and subsequently deplete GSH to suppress the GPX4 enzyme activity

V-Label, ,

doi: 10.3389/fphys.2021.634283 57

Neurodegeneration in COVID-19 patients is a potential consequence of GSH depletion and GPX4 inactivation [350], which would promote lipid peroxidation and ferroptosis [283]