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J Hepatol 43:630636

Minimum effective dose: Start low end of dosing ranges

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Rather than enforcing strict chronological ordering, which may introduce excessive variability, we structured diagnostic sequences by ensuring that a patients prior medical history is retained while capturing deviations from expected patterns

These trials, including STEP-1 through STEP-6, highlighted semaglutides superiority over placebo and other treatments, such as liraglutide, in promoting weight loss and enhancing cardiometabolic parameters, including blood pressure and lipid profiles [6][15]