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Recently, HDAC inhibition by butyrate was shown to affect the expression of P-glycoprotein, an ATP-binding cassette (ABC) protein known as a multi-drug resistance transporter that protects cells via efflux of toxins and xenobiotics (106)

Pathophysiology of Diabetic Retinopathy Chronic hyperglycemia causes overactivity of the mitochondrial electron transport chain, which sets off various cellular alterations