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J Neuroendocrinol (2021) 33(4):e12932

When sorafenib (25 nM) combined with arsenic trioxide (1 M), a synergistic apoptosis inducing effect was observed in FLT3-ITD MOLM13 AML cells, which is related to the inactivation of FLT3-ITD (both expression and phosphorylation) and GSK3, the upregulation of Bax and Bak and the downregulation of Mcl-1