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Lipid peroxidation, ferroptosis, and antioxidants Noriko Noguchi Yoshiro Saito Etsuo Niki Abstract The discovery and conceptualization of ferroptosis as regulated, iron-catalyzed cell death driven by excessive lipid peroxidation triggered re-evaluation of lipid hydroperoxides in connection with health and disease

Methods: EphA2 expression and signaling was assessed in mice fed a high fat diet (HFD) for 8 and 24 weeks, in human liver samples from NASH patients, and in HuH7 cells treated with palmitic acid (FA), low density lipoprotein (LDL), and/or fructose

Uterosome-like vesicles prompt human sperm fertilizing capability

After different treatments, endothelial injury was substantially alleviated

In the ATTAIN-2 trial in patients with diabetes, discontinuation rates due to adverse events were 6.1-9.9% for orforglipron versus 4.1% for placebo