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2.2.3 Others Metformin influences the production of advanced glycation end products (AGEs) and the generation of ROS through the activation of AMPK, inhibition of the receptor for advanced glycation end products/nuclear factor kappa B (RAGE/NF-B) signaling pathway, and modulation of gene expression

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Research indicates that the leakage of iron is associated with neurodegeneration and may exacerbate pathological conditions by inducing inflammatory responses and cellular damage ( During ferroptosis, the deficiency of GPX4 leads to elevated levels of intracellular ROS, triggering oxidative stress (Zheng and Conrad, 2020)