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Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy

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This article summarizes what preclinical studies have explored, including proposed mechanisms such as vascular signaling and inflammatory modulation

Animal studies show minimal toxicity at therapeutic doses over 11 days, with no observed hepatotoxicity, nephrotoxicity, or CNS effects

In a pool of two ZEPBOUND clinical trials for weight reduction (Studies 1 and 2), 0.2% of ZEPBOUND-treated patients had acute pancreatitis confirmed by adjudication (0.14 patients per 100 years of exposure) versus 0.2% of placebo-treated patients (0.15 patients per 100 years of exposure)