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Chronic exposure to CS manifests as pathological changes like heightened oxidative stress, increased lung permeability, loss of tight junctions, epithelial-mesenchymal transition (EMT) all of which contributes to tissue destruction and impaired lung function 4,5,6

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At the same time, the emergence of stem cell technology has brought new hope for the treatment of IVDD, particularly with mesenchymal stem cells (MSCs), which have demonstrated positive effects in disc regeneration due to their excellent proliferation potential and differentiation capabilities ( This article provides a comprehensive review of recent advancements in IVDD research, with a focus on the development and application of biomaterials

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