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Although shikonin presents challenges of advancing as an antimicrobial agent in a clinical setting, it does highlight TrxR as a viable antibacterial target and present scaffolding structure that can be built upon for improved activity

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Biotechnological techniques, such as the cellular thermal shift assay (CETSA) or target-responsive accessibility profiling (TRAP) can be employed to identify the targets of various natural products

Medical note: This article is for education only and does not replace medical advice

Systemic adverse events remain rare in available trials, though long-term safety data in non-dermatology populations is sparse