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IL-10 is a potent anti-inflammatory cytokine produced by immune cells, such as macrophages and NK cells, following alcohol consumption or LPS stimulation [157, 158]

Litwin SE, Komtebedde J, Hu M, Burkhoff D, Hasenfuss G, Borlaug BA, Solomon SD, Zile MR, Mohan RC, Khawash R, Sverdlov AL, Fail P, Chung ES, Kaye DM, Blair J, Eicher JC, Hummel SL, Zirlik A, Westenfeld R, Hayward C, Gorter TM, Demers C, Shetty R, Lewis G, Starling RC, Patel S, Gupta DK, Morsli H, Penicka M, Cikes M, Gustafsson F, Silvestry FE, Rowin EJ, Cutlip DE, Leon MB, Kitzman DW, Kleber FX, Shah SJ

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PGL-1::SNAP::N22 homozygotes were sterile (100%, n = 94), but could be maintained and tested as a fertile heterozygote (PGL-1::SNAP::N22/+)

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