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2019;144(5):1242-1253.e7

Abbreviations NAFLD: Non-alcoholic fatty liver disease ER: Endoplasmic reticulum ROS: Reactive oxygen species NAC: N-acetylcysteine GSH: glutathione HF: high fat diet CD: chow diet PVDF: polyvinylidene difluoride ECHS1: Enoyl-CoA hydratase SREBP1: Sterol regulatory element-binding protein 1 UPR: unfolding protein response p-PERK: protein kinase RNA-like endoplasmic reticulum kinase phosphorylation ATF4: activating transcription factor 4 HSP: heat shock protein ClpP: Clp protease proteolytic subunit HIRI: hepatic ischemia-reperfusion injury JNK: c-Jun N-terminal kinase FAO: fatty acid -oxidation References Obesity: preventing and managing the global epidemic

Empagliflozin, a sodium-glucose co-transporter-2 (SGLT2) inhibitor commonly used for diabetes management, was tested as adjunctive therapy to citalopram in a randomized trial

Before taking this medicine, tell your doctor if you have any other health conditions like kidney or liver diseases as a dose adjustment may be required

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