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Front Endocrinol (Lausanne) 14:1087053

10.1016/j.bbalip.2012.01.013 50 IbbettP.MurinelloS.LoteryA

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However, the RDA is only meant to prevent deficiency, and sometimes we need more than the RDA to support optimal health

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10;508(7495):258-62. doi: 10.1038/nature13198. PMID: 24717514; PMCID: PMC4107212