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10.1021/acsanm.9b02541 103 LemarchandC.GrefR.CouvreurP

1 Introduction Chlorogenic acid (CGA), also called caffeoylquinic acid (CQA), is a dietary polyphenol formed by the esterification of caffeic acid (CA) and quinic acid (QA) ( in vitro , and at 25 M, it reduces reactive oxygen species (ROS) to alleviate oxidative stress in intestinal cells ( eucommia , honeysuckle , and green tea ( The liver is vital for metabolism, the endocrine regulation, and immune response but is often exposed to irritants like viruses, medications, and chemicals ( Building on the aforementioned research findings, we propose the hypothesis that an optimal concentration of CGA confers protection to liver cells via its antioxidant properties

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For example, 16.5% of patients continue to experience headaches after 60 days from the start of the disease, of which 8.4% reported significant headaches even after 180 days post COVID-19 (58, 59)