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shown that mitochondrial dysfunction increased intracellular H 2 O 2 , Fe 2+ levels and might lead to increased production of -OH, resulting in lipid peroxidation and ferroptosis (Takashi et al., 2020)

& Trnka, J

2025 Jun 2;66(6):13

Associations with metabolic diseases In addition to the neuropsychiatric effects and inherited disorders described above, dysregulated Mn homeostasis has been implicated in a wide range of human pathologies

This review cited Kurokawa et al.s results that indicated that patients with Hamilton Depression Rating Scale (HAM-D) scores 8 exhibited reduced microbial diversity compared to healthy donors, and that increased microbial diversity following FMT treatment positively correlated with symptom improvement (Zhang et al., 2025)