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Efficacy and Safety by Cytogenetic Risk Status: Phase 3 Study (ASPIRE) of

This reduces the permeability of the BBB, preventing harmful substances from entering the brain, improving microvascular stability, and alleviating the pathological changes of epilepsy and other brain diseases

The role of hypoxia-inducible factor 1-alpha (HIF-1a) in this context is particularly noteworthy

doi: 10.1001/jamaoncol.2018.3676 140 OhgakiHKleihuesP

Developing selective NOX inhibitors has been quite challenging due to the high degree of similarity in the core catalytic domains of these enzymes, which makes it difficult to achieve selectivity for specific isoforms