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Adding glutathione supplements does not appear to worsen these gastrointestinal effects based on available case reports, but individual responses vary

Son HL, Park HR, Park YJ, Kim SW

Studies have shown that dietary supplementation can improve glutathione production, reduce oxidative stress, and improve insulin sensitivity

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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect