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Downregulation or deficiency of pyruvate kinase leads to ATP depletion which in turn affects cell viability as well as accumulation of the glycolytic intermediates (2,3-diphosphoglycerate (2,3-DPG) that eventually leads to impaired glycolytic flux 46

Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease

But an emerging alternative to traditional treatment methods, called neurofeedback therapy, is gaining popularity

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The most common etiology of liver disease was NAFLD (n=122,191, 79.9%), followed by alcohol (n=13,468, 8.8%), and HCV (n=11,789, 7.7%), and 9,572 (6.3%) individuals had cirrhosis