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To simulate the in vitro expansion for ACI, chondrocytes isolated from healthy donors were expanded to population doubling level (PDL) 9, representing chondrocytes ready for implantation

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Other discrete cortical and white matter brain regions were also analysed, including the postcentral gyrus (PoG), temporal gyrus (TG) - which combines the superior (STG), middle (MTG), and inferior (ITG) temporal gyri -, along with the insula (Ins), claustrum (Cl), anterior cingulate gyrus (ACgG), temporal white matter (tw) and cerebral white matter (cw) (Fig