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Functions with an adjusted p -value (Benjamini-Hochberg correction) 0.05 were considered significantly enriched

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Most common adverse events (bremelanotide arm, RECONNECT): Nausea: 40.0% (vs 1.3% placebo) the primary tolerability concern

Simultaneously, glutathione (GSH), not only an indicator of oxidative stress, but also an important role in detoxification of the acetaminophen metabolite NAPQI, was determined to ascertain whether there was a difference in its depletion in the APAP-treated mice