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In this study, we conducted MR analysis utilizing the TwoSampleMR software package (version 0.6.8) within the R programming environment.We selected two large plasma pQTLs as exposure data and MS as outcome data

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The secondary antibody was Goat Anti-Rabbit IgG H&L Antibody (HRP) at 1:10,000 dilution

(2001) 85:94358, vivii

Collectively, these findings reveal that IRE1 negatively regulates cellular GSH availability and maintains cellular sensitivity to ferroptosis by dampening GCLC expression through its RIDD activity