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Description

Because HepG2 cells are highly de-differentiated compared to normal hepatocytes in situ, and therefore are expected to have a less robust Met cycle and transsulfuration pathway than those found in normal liver, the GSH pool in normal liver could contain a substantially larger proportion of Met-derived S [115, 116, 118120]

Appropriate doses for each participant was calculated based on the body weight measured during the screening visit and the doses were measured using a Gemini-20 millig scale with a precision of 1 mg (American Weight Scales Inc., Cumming, GA, USA)