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doi: 10.3760/cma.j.cn311847-20191018-00271 34

During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]

Your body then has to put it back together, which is an inefficient process

demonstrated that heme oxygenase-1 (HO-1) in hUC-MSCs regulates autophagy and up-regulates CD8 + T cell cycling through activation of the c-Jun N-terminal kinase/ B-cell lymphoma 2 (JNK/Bcl-2) signaling pathway, which contributes to restoring ovarian function in POF mice [112]