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In sheep, the central administration of leptin markedly enhances postprandial thermogenesis in both muscle and diffuse adipose depots (retroperitoneal and gluteal fat)

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10.1038/362031a0 74 HollingerS.HeplerJ

In several clinical trials (Table 3), including those on hyperlipidemic patients with a smoking habit [123], menopausal women with metabolic diseases [124], outpatients of metabolic syndrome [125], and patients bearing Hashimotos thyroiditis [126], administration of black cumin seeds in different formulations significantly improved lipid profile and blood sugar