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Determination of the roGFP2 oxidation state (OxD) revealed complete oxidation of the probe in the periplasm of E

This synergistic antioxidant interplay underscores the potential advantage of multi-nutrient intervention strategies over single-agent supplementation in addressing the complex redox imbalance in this condition

This allows for immediate absorption and rapid onset of action, which can be crucial in emergencies or when quick therapeutic effects are needed

In addition, the reaction of H 2 S with reversibly oxidised protein thiols to form a PrSS , followed by reduction back to a PrSH by the Trx/GSH/Grx systems, prevents irreversible loss of thiols through oxidation to a sulfinic or sulfonic acid 21,22

10.1186/s12967-022-03408-5 219 ZhangY.WangX.LuB.GaoY.ZhangY.LiY.et al (2022c)