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Given the rich lipid content of the nervous system, hemoglobin-derived iron works with lipid peroxidation to induce ferroptosis, which eventually leads to neuronal mitochondrial damage, edema, and apoptosis of neurons and astrocytes

It is thought stress and neuro-inflammatory pathways are mechanisms linking them

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After 2 week acute toxicity and cumulative tests in mice, no statistical difference existed between LAAM GSH-CQD group and normal control group in the parameters from complete blood count and serum biochemistry analyses (Supplementary Fig

The mice also received intraperitoneal injections of 0.5 g Bordetella pertussis toxin (Sigma-Aldrich, MO, USA) suspended in 0.1 ml PBS