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Rats were raised for 2 weeks beforehand to the trial in well-aerated cages under standard temperature (22.5C 2C), relative humidity of 60% 10%, and light (12 h light/dark cycles)

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The studies, which include maternal immune activation (MIA) in mice (poly (I:C)) and prenatal VPA exposure in rats, demonstrate that antipurinergic therapy (APT) with suramin (20 mg/kg) results in improvements of impaired social behaviors

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101,102 Patients with a history of atopy (asthma and allergy) are recommended to receive prophylactic antihistamine 15 minutes prior to N-acetylcysteine administration to eliminate the excess risk of adverse reactions