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Fifteen to thirty minutes before behavioral procedures, mice were given 200 nL intracranial injections of either 0.9% isotonic saline or clozapine N -oxide (CNO) (300 mM

Their study further revealed that these mitochondria are capable of respiration, similar to mammalian erythrocytes, thereby challenging the previously held view that avian erythrocyte energy metabolism relies exclusively on the pentose phosphate pathway and glycolysis

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This effect occurs through a ROS-dependent mild mitochondrial ribosomal stress, which in turn triggers unfolded protein responses (UPR mt ) and thermogenesis in adipose tissue, promoting a high-turnover metabolism and increase resistance to obesity in mice

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