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However, excessive copper intake can induce cell death through cytotoxicity resulted from increased mitochondrial-dependent energy metabolism and ROS accumulation in a process termed cuproptosis [115]

ROS as double-edged swords in cancer Several noncancer cells associate with tumors: among these, cancer-associated fibroblasts (CAFs), particularly represented in the tumor microenvironment (TME), actively contribute to the regulation of tumor homeostasis, promoting tumor progression and the invasion of cancer cells

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Hepatocyte death, a prominent pathological feature of ALD, also plays a crucial role in the development of alcoholic liver inflammation and fibrosis [5]