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Description

Given that inhibition of IGF-IR may paradoxically lead to upregulation of IGF1/2 expression, and IGF1/2 have IGF-IR/InsR-independent functions, it warrants to investigate whether co-targeting IGF and IGF-IR/InsR-A may achieve objective responses

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10.1016/j.plaphy.2013.10.012 53 SchippersJ

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Skeletal muscle protein balance regulation Skeletal muscle mass depends on the rates of protein synthesis and degradation

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Remarkably, GSH depletion significantly decreased the expression of these key fibrogenic factors under both chow and HFD conditions (Figure 3, A and B)

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Microfluidic methods for aptamer selection and characterization

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