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Conversely, sleep deprivation skews immune balance, reducing the number and function of natural killer cells (De Lorenzo et al., 2015), impairing T-cell responsiveness (Tune et al., 2021), and elevating circulating proinflammatory cytokines, thus mimicking an inflammaging-like profile even in younger individuals (Garbarino et al., 2021)

In a longitudinal study involving 369 patients with BD I and BD II over one year, lithium was shown to be more effective in the treatment of BD II [107]

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