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I noticed myself that when taking Curcumin + Piperine at a dose of 1500mg/day, it seemed to have a less noticeable effect the more I used it

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Journal of Biological Chemistry 280, 22925-22936CrossRefGoogle ScholarPubMed 172Calkins, M.J., Jakel, R.J., Johnson, D.A

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This deficiency triggers the excessive release of cyclophilin A (CypA), which perturbs TJ protein localization and activates MMPs to degrade the basement membrane (90)

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