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GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo

Laurel: Kaylee Brooke Donner, sophomore, Deans List, College of Arts and Sciences, psychology

J.MonicaV.SheoranN.MunjalV.SuseelabhaiR.et al

14d), suggesting that the tumors may rely more on importing glutamine from the extracellular environment rather than synthesizing it internally

Additional mechanisms reinforcing this shift include downregulation of the mitochondrial pyruvate carrier, which limits pyruvate entry into mitochondria [204] and activation of AMP-activated protein kinase (AMPK) in response to reduced ATP/AMP ratios, leading to mTOR suppression and metabolic stress adaptation [205,206,207]