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Interestingly, arsenic can promote calpain activation in cell-free systems, indicating that calpain proteases could be a direct target for arsenic-induced metabolic and immune alterations (195)

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119 Intriguingly, researchers have identified lactylation-related genes (AMPD2, PYGL, SLC7A7, SAT1) that are significantly expressed in acute myocardial infarction (AMI), highlighting their potential as early diagnostic biomarkers

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Therefore, it seems highly plausible that oxidative stress in the brain compromises biochemical integrity of the hippocampus and the amygdala